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Neuropeptide Y receptor subtype 1 (NPY Y1) has been implicated in appetite regulation, and antagonists of NPY Y1 are being explored as potential therapeutics for obesity. An NPY Y1 PET tracer is useful for determining the level of target engagement by NPY Y1 antagonists in preclinical and clinical studies. Here we report the synthesis and evaluation of [ 18 F]Y1-973, a novel PET tracer for...
Reference tissue model (RTM) is a compartmental modeling approach that uses reference tissue time activity curve (TAC) as input for quantification of ligand–receptor dynamic PET without blood sampling. There are limitations in applying the RTM for kinetic analysis of PET studies using [ 11 C]Pittsburgh compound B ([ 11 C]PIB). For region of interest (ROI) based kinetic modeling, the...
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