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Iron‐based and indirect iron‐based nanomaterials can be developed for cancer therapy based on ferroptosis via release of their own iron or loaded endogenous iron in lysosomes after endocytosis, which can employ the Fenton reaction to produce reactive oxygen species (ROS) and induce lipid peroxidation. These systems are reviewed by Zijian Zhou, Aiguo Wu, Xiaoyuan Chen, and co‐workers in article number...
Ferroptosis, a new form of regulated cell death that is iron‐ and reactive oxygen species dependent, has attracted much attention in the research communities of biochemistry, oncology, and especially material sciences. Since the first demonstration in 2012, a series of strategies have been developed to induce ferroptosis of cancer cells, including the use of nanomaterials, clinical drugs, experimental...
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