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To investigate the clinical effectiveness of dutasteride in the treatment of benign prostatic hyperplasia by meta-analysis.Several databases were searched from inception to June 2013 for prospective clinical studies comparing dutasteride vs placebo. The continuous outcomes of therapeutic efficacy included International Prostate Symptom Score/American Urological Association Symptom Index, maximum flow...
To investigate how the sodium/calcium exchanger subtype 3 (NCX3) and its reverse mode contribute to the function of interstitial cells of Cajal (ICCs) from the rat bladder.The study used 20 female Wistar rats. We observed the expression of the NCX3 expression in the bladder using reverse transcriptase-polymerase chain reaction and Western blotting. The NCX3 in ICCs was also confirmed by double-labeled...
To investigate the expression and function of T-type calcium channels in the interstitial cells of Cajal in rat bladders.Bladders were harvested from Sprague–Dawley rats. The expression of T-type calcium channels subtypes (α1G, α1H, and α1I) in interstitial cells of Cajal were identified by double-labeled immunofluorescence analysis and reverse transcription-polymerase chain reaction analysis in whole...
To investigate the distribution and effects of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and its isoforms in bladder, especially in bladder interstitial cells of Cajal (ICC). Four HCN isoforms were detected in bladder tissue from rats using reverse transcription–polymerase chain reaction and Western blotting. The HCN1 subtype was observed in bladder ICCs by double-labeled...
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