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BACKGROUND:The monoclonal antibody PAM4 has high specificity for pancreatic ductal adenocarcinoma (PDAC), as well as its precursor lesions, but has not been found to be reactive with normal and benign pancreatic tissues. The objective of the current study was to evaluate a PAM4‐based serum enzyme immunoassay alone and in combination with the carbohydrate antigen (CA) 19‐9 assay for the detection of...
Experimental animal studies were performed with 111 In-labeled PAM4 anti-MUC1 antibody along with 111 In-labeled control antibody. Tumor uptake of radiolabeled PAM4 was significantly higher than for the control antibody at all time points. When normalized to a blood dose of 1500 cGy as an estimate of myelotoxicity, 90 Y-labeled PAM4 would provide 5344...
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