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Key points
L‐type calcium channels in the CNS exist as two subunit forming channels, Cav1.2 and Cav1.3, which are involved in short‐ and long‐term plasticity.
We demonstrate that Cav1.3 but not Cav1.2 is essential for wind‐up.
These results identify Cav1.3 as a key conductance responsible for short‐term sensitization in physiological pain transmission.
We confirm the role of Cav1.2 in a model of...
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