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In article number 1808278, Xian‐Zheng Zhang and co‐workers develop an integrative bioreactor based on engineered bacteria for tumor therapy. This bioreactor displays bacterial tumor tropism and spontaneously supplies localized H2O2 for a therapeutic Fenton‐like reaction, achieving precise and long‐term tumor therapy.
Synthetic biology based on bacteria has been displayed in antitumor therapy and shown good performance. In this study, an engineered bacterium Escherichia coli MG1655 is designed with NDH‐2 enzyme (respiratory chain enzyme II) overexpression (Ec‐pE), which can colonize in tumor regions and increase localized H2O2 generation. Following from this, magnetic Fe3O4 nanoparticles are covalently linked to...
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