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Exposure of cells or organs to sublethal physical or chemical stresses induces disruption of cellular structures and functions. Here, we examined whether Na + -glucose cotransporter (SGLT1) is involved in the recovery from heat shock (HS) injury in porcine renal epithelial LLC-PK 1 cells. Recovery from HS (42 o C for 3 h, then 37 o C for 12 h) increased SGLT1 activity,...
Effects of angiotensin II (ANGII) on regulation of sodium/glucose cotransporter (SGLT1) activity were investigated in LLC-PK 1 cells, renal proximal epithelial cell line. ANGII inhibited α-[ 14 C] methyl-D-glucopyranoside (AMG) uptake into LLC-PK 1 cells in a dose-dependent manner. This inhibition was based on a decrease in maximal transport rate (Vmax) of AMG from 2.20...
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