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3(2H)-isoflavene is a compound related to dichloroflavan with a broad spectrum of antipicornavirus activity. We have studied the effect of this compound on poliovirus type 2 Sabin. The presence of 3(2H)-isoflavene from the beginning of infection, or during the adsorption period only, prevented the shut-off of host translation and viral RNA and protein synthesis; furthermore the drug was not virucidal,...
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