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Purpose
A fundamental goal in the drive to understand and find better treatments for dementia is the identification of the factors that render the aging brain vulnerable to neurodegenerative disease. Recent evidence indicates the integrity of the blood–brain barrier (BBB) to be an important component of functional failure underlying age‐related cognitive decline. Practical and sensitive measurement...
Whether the consolidation and reconsolidation long‐term memory relies on qualitatively different molecular and cellular processes is controversial. Using a novel experimental strategy of combining intrahippocampal antisense oligodeoxynucleotides targeting BDNF or zif268 to the block consolidation or reconsolidation of contextual fear memory respectively, and Affymetrix microarray technology, we identified...
We have applied infrared, Raman and UV-VIS spectroscopy to measure spatially resolved chemical composition and structure of cross-linked polyethylene insulated cables used in the EC-funded Artemis project, both before and after electrical and thermal stressing. The work shows that diffusion of the primary products of chemical crosslinking changes the quasi-parabolic concentration radial profile present...
Microstructural change associated with cortical bone remodeling has been extensively explored with 2D techniques. However, relatively little is known regarding the 3D dynamic microstructure of cortical bone. Therefore, we employed micro-CT imaging to investigate 3D remodeling-related change in the structure of cortical bone porosity across the human lifespan. Anterior femoral midshaft specimens (n=51...
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