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Aim: The therapeutic efficacy of oral hypoglycaemic drugs varies between individuals, and pharmacogenetic factors contribute to this variability. The Gly972Arg polymorphism in the insulin receptor substrate‐1 (IRS‐1) has been shown to play a role in insulin signal transduction and therapeutic failure to sulphonylurea drugs.
Methods: We studied the association between the IRS‐1 polymorphism and the...
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