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Nanoscale electronic devices have the potential to achieve exquisite sensitivity as sensors for the direct detection of molecular interactions, thereby decreasing diagnostics costs and enabling previously impossible sensing in disparate field environments. Semiconducting nanowire-field effect transistors (NW-FETs) hold particular promise, though contemporary NW approaches are inadequate for realistic...
We developed a new type of a microcantilever biosensor resonating at the interface between air and liquid. The cantilever sensor has advantages in high signal-to-noise ratio (SNR) and high quality factor (Q-factor) for detecting bio-reactions because liquid damping acts on only one-side, and because there is no obstacle between detection, excitation lasers and the cantilever. (Fig. 1 (c)) Using the...
This paper describes a miniaturized oxygen sensor array integrated with heaters and temperature sensors and a LabVIEW-based measurement system which exactly can measure a cellular respiration level in a solution containing cells simultaneously. The designed oxygen sensor consists of Clark-type sensors, heaters, and temperature sensors of 2 times 3 array type on the substrate. 18 mum PDMS was used...
It is demonstrated that the etched-core fiber Bragg grating sensor can be used to detect down to a monolayer of biological and chemical agents immobilized on the surface of the fiber. Theoretical models based on calculating the effective index of the surrounding medium in the presence of immobilized layer(s) were developed and confirmed experimentally by immobilizing a monolayer of 3-aminopropyl-monoethoxydimethyl-silane...
In this paper, we show that the fiber Bragg grating sensor can be used to detect and differentiate the number of layers that are deposited on the fiber surface. A theory was developed for calculating the wavelength change as thin films of biological and chemical layers are immobilized on the surface of the fiber in the presence of a surrounding medium. A theory is developed and verified experimentally...
Recent developments for biosensors have been mainly focused on miniaturization and exploratory use of new materials. It should be emphasized that the absence of a novel "in-situ self-calibration/diagnosis technique" that is not connected to an external apparatus is a key obstacle to the realization of a biosensor for continuous use with minimum attendance. In order to address this issue,...
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