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Aβ1-40 and perlecan (Aβ+perlecan) were infused into rat hippocampus for 1 week via osmotic pumps. At the end of the infusion a deposit of Aβ immunoreactive material was found surrounding the infusion site. No neurons could be identified within this Aβ deposit. The neuron-free area resulting from Aβ+perlecan was significantly larger than that found after infusions of Aβ40-1 and perlecan (reverse Aβ+perlecan),...
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