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p21, the product of the WAF1/CIP1/SDI1/mda-6 gene, is an inhibitor of cyclin-dependent kinases. In cell cultures p21 is induced by p53-dependent and p53-independent pathways by DNA damage and induction of differentiation. We investigated p21 RNA and immuno-histochemical expression in 43 non-small cell lung carcinomas and corresponding normal lung samples previously investigated for p53 and WAF1...
Cells proliferation is regulated by molecules involved in different steps of the cell cycle. Cyclins and their catalytic subunits, the cyclin dependent kinases (CDKs), are activators of cell division. On the other hand, a family of cyclin-CDKs inhibitor (CDI) proteins can bind the CDKs inducing growth arrest. This family includes p21, encoded by the WAF1 gene, which has been described as the critical...
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