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Background
Severe asthma exacerbations increase the risk of accelerated lung function decline. This analysis examined the effect of dupilumab on forced expiratory volume in 1 s (FEV1) in patients with moderate‐to‐severe asthma and elevated type 2 biomarkers from phase 3 LIBERTY ASTHMA QUEST (NCT02414854).
Methods
Changes from baseline in pre‐ and post‐bronchodilator (BD) FEV1 and 5‐item Asthma...
Background
Mepolizumab and omalizumab are treatments for distinct but overlapping severe asthma phenotypes.
Objective
To assess if patients eligible for both biologics but not optimally controlled with omalizumab experience improved asthma control when switched directly to mepolizumab.
Methods
OSMO was a multicenter, open‐label, single‐arm, 32‐week trial in patients with ≥2 asthma exacerbations...
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