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Gastrin is initially synthesized as a large precursor that requires endoproteolytic cleavage by a prohormone convertase (PC) for bioactivation. Gastric antral G-cells process progastrin at Arg 94 Arg 95 and Lys 74 Lys 75 residues generating gastrin heptadecapeptide (G17-NH 2 ). Conversely, duodenal G-cells process progastrin to gastrin tetratriacontapeptide...
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