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Tumor immunotherapy is an important tool in oncology treatment. However, only a small percentage of patients have an effective immune response to tumor immunotherapy due to the poor infiltration of pro‐inflammatory immune cells in immune “cold” tumors and an immunosuppressive network in the tumor microenvironment (TME). Ferroptosis has been widely used as a novel strategy to enhance tumor immunotherapy...
Intracerebral hemorrhage (ICH) remains a significant cause of morbidity and mortality around the world, and surgery is still the most direct and effective way to remove ICH. However, the potential risks brought by surgery, such as normal brain tissue damage, post‐operative infection, and difficulty in removing deep hematoma, are still the main problems in the surgical treatment of ICH. Activation...
In article number 2007486, Liang Cheng, Chaoliang Tan, and co‐workers report the activation of the near infrared absorption of layered metal oxide nanomaterials via a simple lithium treatment‐induced structural engineering, making them promising as robust biodegradable nanoagents for photothermal cancer therapy in the second near infrared window.
Layered metal oxides including MoO3 and WO3 have been widely explored for biological applications owing to their excellent biocompatibility, low toxicity, and easy preparation. However, they normally exhibit weak or negligible near‐infrared (NIR) absorption and thus are inefficient for photo‐induced biomedical applications. Herein, the structural engineering of layered MoO3 and WO3 nanostructures...
The ideal bone repair material should firstly recognize and recruit osteoblast precursor cells to initiate the repair process, then promote the differentiation of osteoblasts and accelerate the mineralization of the extracellular matrix (ECM). Here, a bioinspired staged bone regeneration strategy which loads bone morphogenetic protein2 (BMP2)‐modified black phosphorus (BP@BMP2) nanosheets to a polylactic...
Nanozymes with high catalytic activity and great stability have attracted increasing interests as the promising alternative to natural enzymes for applications in various fields. In this study, a new type of highly efficient peroxidase‐like nanozymes based on FeWOX nanosheets (NSs) synthesized by a thermal‐decomposition method is reported. Owing to the sheet‐structure with maximized utilization of...
Drug‐eluting stents (DESs) are promising candidates for treating human oesophageal cancer. However, the use of DESs to assist photodynamic therapy (PDT) of orthotopic oesophageal tumors is not yet demonstrated to the best of current knowledge. Herein, through an electrospinning technology it is shown that oxygen‐producing manganese dioxide nanoparticles are embedded into elelctrospun fibers, which...
Development of nanoagents with strong near‐infrared (NIR) absorbance and high photothermal conversion capacity is highly desired for efficient photoacoustic (PA) imaging and photothermal therapy of cancers. Herein, surfactant‐stripped micelles with photostable near‐infrared dye, β‐thiophene‐fused BF2‐azadipyrromethene (aza‐BDTP), are prepared in the presence of paclitaxel (PTX) with Pluronic F127...
Recently, the development of multifunctional theranostic nanoplatforms to realize tumor‐specific imaging and enhanced cancer therapy via responding or modulating the tumor microenvironment (TME) has attracted tremendous interests in the field of nanomedicine. Herein, tungsten disulfide (WS2) nanoflakes with their surface adsorbed with iron oxide nanoparticles (IONPs) via self‐assembly are coated with...
Combining chemotherapy and radiotherapy (chemoradiotherapy) has been widely applied in many clinical practices, showing promises in enhancing therapeutic outcomes. Nontoxic nanocarriers that not only are able to deliver chemotherapeutics into tumors, but could also act as radiosensitizers to enhance radiotherapy would thus be of great interest in the development of chemoradiotherapies. To achieve...
While position emission tomography (PET) is an important molecular imaging technique for both preclinical research and clinical disease diagnosis/prognosis, chelator‐free radiolabeling has emerged as a promising alternative approach to label biomolecules or nanoprobes in a facile way. Herein, starting from bottom‐up synthesized WS2 nanoflakes, this study fabricates a unique type of WS2/WOx nanodots,...
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