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To gain a better understanding of the biological consequences of the exposure of tumor cells to selenium, we evaluated the selenium-dependent responses of two selenoproteins (glutathione peroxidase and the recently characterized 15-kDa selenoprotein) in three human glioma cell lines. Protein levels, mRNA levels, and the relative distribution of the two selenocysteine tRNA isoacceptors (designated...
The single rat selenocysteine tRNA (tRNA [Ser]Sec ) locus, including flanking sequence, was isolated by molecular cloning and its nucleotide (nt) sequence determined. In addition to the identification of likely regulatory elements 5 of this gene, this analysis also revealed a novel 3 repeat element consisting of three and a half repetitions of a 34-nt...
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