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Pain associated with cancer, particularly when tumors metastasize to bone, is often severe and debilitating. Better understanding of the neurobiological mechanisms underlying cancer pain will likely lead to the development of more effective treatments. The aim of this study was to characterize changes in response properties of nociceptive dorsal horn neurons following implantation of fibrosarcoma...
Electrophysiological recordings were made from mechanosensitive nociceptors innervating hairy skin of the rat hindpaw, and responses evoked by a wide range of noxious cold stimuli (20 to -12°C) were determined. All Aδ and C nociceptors sampled were excited by noxious cold. Response thresholds of Aδ nociceptors were significantly higher (colder stimulus temperatures) than thresholds of C fibers,...
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