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A Compton camera-based detector system for photon detection from nuclear reactions induced by proton (or heavier ion) beams is under development at LMU Munich, targeting the online range verification of the particle beam in hadron therapy via prompt-gamma imaging. The detector is designed to be capable to reconstruct the photon source origin not only from the Compton scattering kinematics of the primary...
In proton radiation therapy, a relative biological effectiveness (RBE) equal to 1.1 is currently assumed, although biological experiments show that it is not constant. The purpose of this study was to quantify the uncertainties of a published biological model and explore their impact on variable RBE treatment plan (TP) optimization.Two patient cases with a high and a low (α/β)x tumor were investigated...
A Compton Camera (CC) prototype is currently being commissioned at the Ludwig-Maximilians-Universität München. It is planned to be used for studying in-vivo proton or ion beam range monitoring capabilities by means of prompt gamma (PG) rays, exploiting Compton scattering kinematics in order to reconstruct a PG based image correlated to the beam range. The camera consists of a monolithic LaBr3(Ce)...
The sensitivity of ion therapy to inaccuracies in treatment planning and delivery procedures demands the development of imaging techniques capable of accurate assessment of the Relative (to water) ion Stopping Power (RSP). The investigated tomographic carbon ion CT (iCT) imaging setup consists of a prototype integration-mode detector working as range telescope using active scanning ion beam delivery...
Prompt secondary radiations such as gamma rays and protons can be used for ion-range monitoring during ion therapy either on an energy-slice basis or on a pencil-beam basis. We present a review of the ongoing activities in terms of detector developments, imaging, experimental and theoretical physics issues concerning the correlation between the physical dose and hadronic processes.
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