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We propose a heuristic algorithm, called ARG4WG, to build plausible ancestral recombination graphs (ARGs) from thousands of whole genome samples. By using the longest shared end for recombination inference, ARG4WG constructs ARGs with small numbers of recombination events that perform well in association mapping on genome-wide association studies.
Discovering human disease-causing genes (disease genes in short) is one of the most challenging problems in bioinformatics and biomedicine, as most diseases are related in some way to our genes. Various methods have been proposed to exploit existing data sources for solving the problem. We aim to develop a novel method to predict disease genes that takes into account the imbalance between known disease...
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