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Key points
Muscle‐specific genetic ablation of p21‐activated kinase (PAK)2, but not whole‐body PAK1 knockout, impairs glucose tolerance in mice.
Insulin‐stimulated glucose uptake partly relies on PAK2 in glycolytic extensor digitorum longus muscle
By contrast to previous reports, PAK1 is dispensable for insulin‐stimulated glucose uptake in mouse muscle.
Abstract
The group I p21‐activated kinase...
The effect of acute inhibition of both mTORC1 and mTORC2 on metabolism is unknown. A single injection of the mTOR kinase inhibitor, AZD8055, induced a transient, yet marked increase in fat oxidation and insulin resistance in mice, whereas the mTORC1 inhibitor rapamycin had no effect. AZD8055, but not rapamycin reduced insulin-stimulated glucose uptake into incubated muscles, despite normal GLUT4 translocation...
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