Folke Knutson

artykuł

The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates

Ouada Nebie, David Devos, Valérie Vingtdeux, Lassina Barro, więcej

Journal of Biomedical Science > 2019 > 26 > 1 > 1-14

Background Effective neurorestorative therapies of neurodegenerative diseases must be developed. There is increasing interest in using human platelet lysates, rich in neurotrophic factors, as novel disease-modifying strategy of neurodegeneration. To ensure virus safety, pathogen reduction treatments should be incorporated in the preparation process of the platelet concentrates used as source material...

artykuł

A double‐virally‐inactivated (Intercept–solvent/detergent) human platelet lysate for in vitro expansion of human mesenchymal stromal cells

Lassina Barro, Yu‐Ting Su, Ouada Nebie, Yu‐Wen Wu, więcej

Transfusion > 59 > 6 > 2061 - 2073

BACKGROUND Pooled human platelet lysate (HPL) can replace fetal bovine serum (FBS) as xeno‐free supplement for ex vivo expansion of mesenchymal stromal cells (MSCs). We evaluate here whether a double‐virally‐inactivated HPL (DVI‐HPL) prepared from expired Intercept‐treated platelet concentrates (PCs) and treated by solvent/detergent (S/D) can be used for MSC expansion. STUDY DESIGN AND METHODS...

artykuł

Standardizing the freeze‐thaw preparation of growth factors from platelet lysate

Gabriel Strandberg, Felix Sellberg, Pehr Sommar, Martin Ronaghi, więcej

Transfusion > 57 > 4 > 1058 - 1065

BACKGROUND Over the past decades, the focus on the regenerative properties of platelets (PLTs) has intensified and many PLT‐derived growth factors are readily used in medical settings. A general lack of standardization in the preparation of these growth factors remains, however, and this study therefore examines the dynamics of growth factors throughout the freeze‐thaw procedure. STUDY DESIGN AND...

artykuł

Composition of growth factors and cytokines in lysates obtained from fresh versus stored pathogen-inactivated platelet units

Felix Sellberg, Erik Berglund, Martin Ronaghi, Gabriel Strandberg, więcej

Transfusion and Apheresis Science > 2016 > 55 > 3 > 333-337

Platelet lysate is a readily available source of growth factors, and other mediators, which has been used in a variety of clinical applications. However, the product remains poorly standardized and the present investigation evaluates the composition of platelet lysate obtained from either fresh or stored pathogen-inactivated platelet units.Platelet pooled units (n = 10) were obtained from healthy...

artykuł

Inflammatory cytokines in serum samples of healthy blood donors

Felix Sellberg, Martin Ronaghi, Folke Knutson, David Berglund

Transfusion and Apheresis Science > 2016 > 55 > 2 > 246-247

artykuł

Improving the anti‐inflammatory effect of serum eye drops using allogeneic serum permissive for regulatory T cell induction

Per‐Anton Stenwall, Marcus Bergström, Peter Seiron, Felix Sellberg, więcej

Acta Ophthalmologica > 93 > 7 > 654 - 657

PurposeTo investigate the cytokine composition and anti‐inflammatory effects of allogeneic serum preparations for improved use as serum eye drops. MethodsSerum of 15 healthy blood donors was extensively screened for cytokines, including IL‐1β, IL‐2, IL‐4, IL‐5, IL‐6, IL‐9, IL‐10, IL‐12p70, IL‐13, IL‐15, 1L‐17A, E and F, IL‐21, IL‐22, IL‐23, IL‐27, IL‐28A, IL‐31, IL‐33, granulocyte macrophage colony‐stimulating...

artykuł

Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor

Johan W. Lagerberg, Jose A. Salado‐Jimena, Helena Löf, Ido J. Bontekoe, więcej

Transfusion > 53 > 8 > 1798 - 1807

BackgroundThe Reveos system (Terumo BCT) is a fully automated device able to process four whole blood (WB) units simultaneously into a plasma unit, a red blood cell (RBC) unit, and an interim platelet (PLT) unit (IPU). Multiple IPUs can be pooled to form a transfusable PLT product. The aim of our study was to evaluate the quality of components made with the Reveos system from either fresh (2‐8 hr)...

artykuł

A multi‐centre study of therapeutic efficacy and safety of platelet components treated with amotosalen and ultraviolet A pathogen inactivation stored for 6 or 7 d prior to transfusion

Miguel Lozano, Folke Knutson, René Tardivel, Joan Cid, więcej

British Journal of Haematology > 153 > 3 > 393 - 401

Bacteria in platelet components (PC) may result in transfusion‐related sepsis (TRS). Pathogen inactivation of PC with amotosalen (A‐PC) can abrogate the risk of TRS and hence facilitate storage to 7 d. A randomized, controlled, double‐blinded trial to evaluate the efficacy and safety of A‐PC stored for 6–7 d was conducted. Patients were randomized to receive one transfusion of conventional PC (C‐PC)...

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Wyniki wyszukiwania dla: Folke Knutson

The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates

A double‐virally‐inactivated (Intercept–solvent/detergent) human platelet lysate for in vitro expansion of human mesenchymal stromal cells

Standardizing the freeze‐thaw preparation of growth factors from platelet lysate

Composition of growth factors and cytokines in lysates obtained from fresh versus stored pathogen-inactivated platelet units

Inflammatory cytokines in serum samples of healthy blood donors

Improving the anti‐inflammatory effect of serum eye drops using allogeneic serum permissive for regulatory T cell induction

Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor

A multi‐centre study of therapeutic efficacy and safety of platelet components treated with amotosalen and ultraviolet A pathogen inactivation stored for 6 or 7 d prior to transfusion

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