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In this study, we probed into the related mechanism underlying the role of Tanshinone IIA (TIIA) in RA fibroblast‐like synoviocytes (RA‐FLSs). We constructed a mouse model of RA using the collagen‐induced arthritis (CIA) method. Gain‐ or loss‐of‐function approaches were used to manipulate matrix metalloproteinase9 (MMP9), receptor for advanced glycation end product (RAGE), and toll‐like receptor 9...
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