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One or several short cycles of ischemia/reperfusion before (preconditioning) or after (postconditioning) a sustained coronary occlusion with subsequent reperfusion reduce the ultimate infarct size. The protection is potent, but limited to a narrow time frame. In animal experiments, a complex signal transduction cascade was identified which results specifically in a reduction of reperfusion injury...
Die Ruptur einer atherosklerotischen Plaque ist das Schlüsselereignis in der Pathogenese eines akuten Koronarsyndroms und eine häufige Komplikation bei Koronarinterventionen. Eine Plaqueruptur führt nicht zwangsläufig zum thrombotischen Gefäßverschluss mit nachfolgendem Myokardinfarkt. Bei kleineren Plaqueeinrissen kann atheromatöses und/oder thrombotisches Material in die Mikrozirkulation geschwemmt...
Duringnormoperfusion, both myocardial blood flow and contractile function are heterogeneously distributed throughout the left ventricle. Midwall segment shortening is greater at the apex than at the base of the left ventricle, and greater in the anterior than in the posterior wall. Also, transmural heterogeneity of myocardial deformation exists, with greater segment shortening and wall thickening...
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