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A reversible surface‐enhanced Raman spectroscopy (SERS)‐based sensor with stem loop aptamers is reported. It is capable of detecting its target molecule at concentrations below the micromolar level and of delivering robust signals from events involving fewer than ten target molecules. Washing the sensor with buffer causes the SERS spectrum to revert to its pre‐detection‐event form, fully restoring...
On page 4152, Martin Moskovits and co‐workers report a reversible surface‐enhanced Raman spectroscopy (SERS)‐based sensor consisting of gold nanoparticles tethered with stem loop aptamers capable of delivering robust signals from sensing events involving as few as two target molecules. Washing the sensor with buffer causes the SERS spectrum to revert to its pre‐detection‐event form, fully restoring...
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