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Parenteral vaccines typically can prime systemic humoral immune response, but with limited effects on cellular and mucosal immunity. Here, a subcutis‐to‐intestine cascade for navigating nanovaccines to address this limitation is proposed. This five‐step cascade includes lymph nodes targeting, uptaken by dendritic cells (DCs), cross‐presentation of antigens, increasing CCR9 expression on DCs, and driving...