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Interactions between the transducin α-subunit (Gα t ) and the cGMP phosphodiesterase γ-subunit (PDEγ) are critical not only for turn-on but also turn-off of vertebrate visual signal transduction. Elucidation of the signaling mechanisms dominated by these interactions has been restrained by the lack of atomic structures for full-length Gα t /PDEγ complexes, in particular, the signaling-state...
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