Search results for: Seiji Mabuchi

Items from 1 to 20 out of 40 results

article

Extraovarian seromucinous borderline tumor: Case report and literature review

Mina Sakata, Seiji Mabuchi, Michihide Maeda, Shigenori Nagata, more

Journal of Obstetrics and Gynaecology Research > 50 > 7 > 1263 - 1267

Seromucinous borderline tumors (SMBT) are papillary neoplasms without invasive capabilities. Originally categorized as ovarian tumors, SMBT, being an endometriosis‐related tumor, can manifest beyond the ovaries. To date, only four cases of extraovarian SMBT have been documented in literature. In this report, we present our experience with the first case of SMBT in the uterine cervix, which exhibited...

article

Impact of lymphadenectomy in patients with locally recurrent or persistent cervical cancer treated with salvage hysterectomy

Seiji Mabuchi, Naoko Komura, Michiko Kodama, Shinya Matsuzaki, more

Journal of Obstetrics and Gynaecology Research > 49 > 2 > 717 - 724

Aim To investigate the role of lymphadenectomy (LND) in locally recurrent or persistent cervical cancer patients treated with salvage hysterectomy. Methods Locally recurrent or persistent cervical cancer patients treated with salvage hysterectomy, with or without LND, were identified. Patients were divided into two groups according to the status of radiologic evidence of lymph node metastasis,...

article

Subsequent menstrual disorder after spontaneous menarche in Turner syndrome

Naoko Komura, Seiji Mabuchi, Kenjiro Sawada, Yukihiro Nishio, more

Clinical Endocrinology > 95 > 1 > 163 - 168

Objective Turner syndrome (TS) is a congenital disease characterized by delayed puberty, ovarian dysgenesis and short stature. Although most patients are diagnosed with primary amenorrhea, approximately 15‐20% of patients with TS are reported to have spontaneous menarche. However, little is known about their menstruation status after spontaneous menarche. In the current study, we investigated the...

article

Radiotherapy for isolated recurrent epithelial ovarian cancer: A single institutional experience

Naoko Komura, Seiji Mabuchi, Fumiaki Isohashi, Eriko Yokoi, more

Journal of Obstetrics and Gynaecology Research > 45 > 6 > 1173 - 1182

Aim To evaluate the efficacy and toxicity of external beam radiotherapy (RT) for isolated recurrent epithelial ovarian cancer (EOC). Methods Twenty‐four isolated recurrent EOC patients treated with RT at Osaka University Hospital between January 2000 and January 2017 were included in the current study. Data regarding the primary or recurrent diseases, follow‐up findings, and efficacy or toxicities...

article

Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells

Akihiko Yoshimura, Kenjiro Sawada, Koji Nakamura, Yasuto Kinose, more

BMC Cancer > 2018 > 18 > 1 > 1-13

Background microRNAs (miRNAs) stably exist in circulating blood and are encapsulated in extracellular vesicles such as exosomes. The aims of this study were to identify which exosomal miRNAs are highly produced from epithelial ovarian cancer (EOC) cells, to analyze whether serum miRNA can be used to discriminate patients with EOC from healthy volunteers, and to investigate the functional role of exosomal...

article

Lurbinectedin (PM01183), a selective inhibitor of active transcription, effectively eliminates both cancer cells and cancer stem cells in preclinical models of uterine cervical cancer

Eriko Yokoi, Seiji Mabuchi, Kotaro Shimura, Naoko Komura, more

Investigational New Drugs > 2019 > 37 > 5 > 818-827

Summary Objective The objective of this study was to evaluate the antitumor effects of lurbinectedin on cervical cancer with a special focus on its effects on cancer stem cells (CSCs). Methods Using two cervical cell lines (ME180 and CaSki cells), the antitumor effects of lurbinectedin were assessed in vitro using the MTS assay and colony formation assay. The growth inhibitory effects of paclitaxel...

article

Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types

Masaki Kobayashi, Kenjiro Sawada, Koji Nakamura, Akihiko Yoshimura, more

Journal of Ovarian Research > 2018 > 11 > 1 > 1-10

Background microRNAs (miRNAs) stably exist in circulating blood encapsulated in extracellular vesicles such as exosomes; therefore, serum miRNAs have the potential to serve as novel cancer biomarkers. New diagnostic markers to detect high grade serous ovarian cancer (HGSOC) are urgently needed. The aim of this study was to identify miRNAs specific to HGSOC and analyze whether serum miRNA can discriminate...

article

Anti‐glypican‐1 antibody‐drug conjugate exhibits potent preclinical antitumor activity against glypican‐1 positive uterine cervical cancer

Satoko Matsuzaki, Satoshi Serada, Kosuke Hiramatsu, Satoshi Nojima, more

International Journal of Cancer > 142 > 5 > 1056 - 1066

Glypican‐1 (GPC1) is highly expressed in solid tumors, especially squamous cell carcinomas (SCCs), and is thought to be associated with disease progression. We explored the use of a GPC1‐targeted antibody‐drug conjugate (ADC) as a novel treatment for uterine cervical cancer. On immunohistochemical staining, high expression levels of GPC1 were detected in about 50% of uterine cervical cancer tissues...

article

Predictors of distant relapse in patients with FIGO stage IIB–IVA cervical cancer treated with definitive radiotherapy

Mika Okazawa‐Sakai, Seiji Mabuchi, Fumiaki Isohashi, Atsushi Kawashima, more

Journal of Obstetrics and Gynaecology Research > 43 > 11 > 1743 - 1750

Aim To investigate the predictors of distant relapse in International Federation of Gynecology and Obstetrics (FIGO) stage IIB–IVA cervical cancer patients treated with definitive radiotherapy (RT). Methods The clinical data of 219 patients with FIGO stage IIB–IVA cervical cancer treated with definitive RT between January 1997 and December 2011 were retrospectively reviewed. The cumulative distant...

article

Combination chemotherapy with irinotecan and gemcitabine for taxane/platinum-resistant/refractory ovarian and primary peritoneal cancer: a multicenter phase I/II trial (GOGO-Ov 6)

Kiyoshi Yoshino, Shoji Kamiura, Takeshi Yokoi, Ruriko Nakae, more

Cancer Chemotherapy and Pharmacology > 2017 > 80 > 6 > 1239-1247

Purpose To develop a new therapeutic strategy for taxane/platinum-resistant/refractory ovarian and primary peritoneal cancers, we evaluated the feasibility and efficacy of irinotecan and gemcitabine combination chemotherapy. Methods Patients with taxane/platinum-resistant/refractory cancer received escalating doses of irinotecan and gemcitabine (level 1: 80 and 800 mg/m², respectively; level 2:...

article

Comparison of clinical utility between neutrophil count and neutrophil–lymphocyte ratio in patients with ovarian cancer: a single institutional experience and a literature review

Naoko Komura, Seiji Mabuchi, Eriko Yokoi, Katsumi Kozasa, more

International Journal of Clinical Oncology > 2018 > 23 > 1 > 104-113

Objective We retrospectively investigated the prognostic significance and clinical utility of pretreatment neutrophilia and elevated neutrophil–lymphocyte ratio (NLR) in patients with epithelial ovarian cancer. Methods Clinical data were collected from 344 surgically staged ovarian cancer patients between April 2007 and March 2016 and retrospectively reviewed. Neutrophilia and elevated NLR were...

article

Phase II basket trial of perifosine monotherapy for recurrent gynecologic cancer with or without PIK3CA mutations

Kosei Hasegawa, Masahiro Kagabu, Mika Mizuno, Katsutoshi Oda, more

Investigational New Drugs > 2017 > 35 > 6 > 800-812

Summary Objective Perifosine exhibits anti-tumor activity by inhibiting AKT phosphorylation. The purpose of this phase II basket trial was to evaluate the efficacy and safety of perifosine monotherapy for ovarian, endometrial, and cervical cancers. Methods Recurrent or persistent ovarian, endometrial, or cervical cancer patients were assigned to PIK3CA wild-type or mutant groups. Each patient received...

article

The significance of tumor-associated neutrophil density in uterine cervical cancer treated with definitive radiotherapy

Yuri Matsumoto, Seiji Mabuchi, Katsumi Kozasa, Hiromasa Kuroda, more

Gynecologic Oncology > 2017 > 145 > 3 > 469-475

The aim of this study was to investigate the prognostic significance of tumor-associated neutrophil (TAN) density in cervical cancer patients that were treated with definitive radiotherapy.The baseline characteristics and outcome data of FIGO stages IB-IVA cervical cancer patients who were treated with definitive radiotherapy between January 1996 and December 2011 were collected. Using biopsy samples...

article

The efficacy of surgical treatment of recurrent or persistent cervical cancer that develops in a previously irradiated field: a monoinstitutional experience

Seiji Mabuchi, Yuri Matsumoto, Naoko Komura, Masaaki Sawada, more

International Journal of Clinical Oncology > 2017 > 22 > 5 > 927-936

Background There are no guidelines about the selection of recurrent cervical cancer patients for salvage surgery. Methods Patients who developed recurrent or persistent cervical cancer in a previously irradiated field and were subsequently treated with salvage surgery (the surgery group) or palliative care alone (the palliative group) were identified. Patient characteristics, treatment-related complications,...

article

Predictors for recurrent/persistent high-grade intraepithelial lesions and cervical stenosis after therapeutic conization: a retrospective analysis of 522 cases

Yusuke Tanaka, Yutaka Ueda, Mamoru Kakuda, Satoshi Kubota, more

International Journal of Clinical Oncology > 2017 > 22 > 5 > 921-926

Objective The objective of the study is to identify the risk factors associated with recurrent/persistent disease and cervical stenosis after conization. Methods Five hundred twenty-two (522) cases of high-grade intraepithelial lesions treated by conization were retrospectively reviewed. Risk factors associated with recurrent/persistent disease were analyzed by univariate and multivariate analysis...

article

Salvage high-dose-rate brachytherapy for isolated vaginal recurrence of endometrial cancer

Sungjae Baek, Fumiaki Isohashi, Hiroko Yamaguchi, Seiji Mabuchi, more

Brachytherapy > 2016 > 15 > 6 > 812-816

We have retrospectively analyzed the outcomes of high-dose-rate (HDR) brachytherapy as a salvage therapy for vaginal recurrence of endometrial cancer.From 1997 to 2012, salvage HDR brachytherapy was performed in 43 patients. The median age was 64 years (range, 41–88 years). HDR brachytherapy was performed by interstitial brachytherapy in 34 patients (79%) and by intracavity brachytherapy in nine patients...

article

A phase II study of postoperative concurrent carboplatin and paclitaxel combined with intensity-modulated pelvic radiotherapy followed by consolidation chemotherapy in surgically treated cervical cancer patients with positive pelvic lymph nodes

Seiji Mabuchi, Fumiaki Isohashi, Takeshi Yokoi, Masahiko Takemura, more

Gynecologic Oncology > 2016 > 141 > 2 > 240-246

A phase II study was conducted to evaluate the efficacy and toxicity of carboplatin plus paclitaxel (TC)-based postoperative concurrent chemoradiotherapy (CCRT) followed by TC-based consolidation chemotherapy in surgically-treated early-stage cervical cancer patients.Women with surgically-treated early-stage cervical cancer with positive pelvic lymph nodes were eligible for this study. The patients...

article

Targeting Inhibitor of κB Kinase β Prevents Inflammation-Induced Preterm Delivery by Inhibiting IL-6 Production from Amniotic Cells

Aska Toda, Kenjiro Sawada, Tomoyuki Fujikawa, Atsuko Wakabayashi, more

The American Journal of Pathology > 2016 > 186 > 3 > 616-629

Preterm delivery (PTD) remains a serious challenge in perinatology. Intrauterine infection and/or inflammation, followed by increased inflammatory cytokines, represented by IL-6, are involved in this pathology. Our aim was to identify IL-6–producing cells in the placenta and to analyze the potential of targeting IκB kinase β (IKKβ) signaling to suppress IL-6 production for the treatment of PTD. Immunohistochemical...

article

Prognostic significance of systemic neutrophil and leukocyte alterations in surgically treated endometrial cancer patients: A monoinstitutional study

Ryoko Takahashi, Seiji Mabuchi, Mahiru Kawano, Tomoyuki Sasano, more

Gynecologic Oncology > 2015 > 137 > 1 > 112-118

The aim of this study was to investigate the prognostic significance of an elevated neutrophil count at the time of the initial diagnosis in patients with surgically treated endometrial cancer.The baseline characteristics and outcome data of patients who were diagnosed with endometrial cancer between January 2000 and December 2010 were collected and retrospectively reviewed. The patients were separated...

article

The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer

Seiji Mabuchi, Hiromasa Kuroda, Ryoko Takahashi, Tomoyuki Sasano

Gynecologic Oncology > 2015 > 137 > 1 > 173-179

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway plays a critical role in the malignant transformation of human tumors and their subsequent growth, proliferation, and metastasis. Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is frequently activated in ovarian cancer, especially in clear cell carcinoma and endometrioid adenocarcinoma...

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INFONA - science communication portal

Search results for: Seiji Mabuchi

Extraovarian seromucinous borderline tumor: Case report and literature review

Impact of lymphadenectomy in patients with locally recurrent or persistent cervical cancer treated with salvage hysterectomy

Subsequent menstrual disorder after spontaneous menarche in Turner syndrome

Radiotherapy for isolated recurrent epithelial ovarian cancer: A single institutional experience

Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells

Lurbinectedin (PM01183), a selective inhibitor of active transcription, effectively eliminates both cancer cells and cancer stem cells in preclinical models of uterine cervical cancer

Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types

Anti‐glypican‐1 antibody‐drug conjugate exhibits potent preclinical antitumor activity against glypican‐1 positive uterine cervical cancer

Predictors of distant relapse in patients with FIGO stage IIB–IVA cervical cancer treated with definitive radiotherapy

Combination chemotherapy with irinotecan and gemcitabine for taxane/platinum-resistant/refractory ovarian and primary peritoneal cancer: a multicenter phase I/II trial (GOGO-Ov 6)

Comparison of clinical utility between neutrophil count and neutrophil–lymphocyte ratio in patients with ovarian cancer: a single institutional experience and a literature review

Phase II basket trial of perifosine monotherapy for recurrent gynecologic cancer with or without PIK3CA mutations

The significance of tumor-associated neutrophil density in uterine cervical cancer treated with definitive radiotherapy

The efficacy of surgical treatment of recurrent or persistent cervical cancer that develops in a previously irradiated field: a monoinstitutional experience

Predictors for recurrent/persistent high-grade intraepithelial lesions and cervical stenosis after therapeutic conization: a retrospective analysis of 522 cases

Salvage high-dose-rate brachytherapy for isolated vaginal recurrence of endometrial cancer

A phase II study of postoperative concurrent carboplatin and paclitaxel combined with intensity-modulated pelvic radiotherapy followed by consolidation chemotherapy in surgically treated cervical cancer patients with positive pelvic lymph nodes

Targeting Inhibitor of κB Kinase β Prevents Inflammation-Induced Preterm Delivery by Inhibiting IL-6 Production from Amniotic Cells

Prognostic significance of systemic neutrophil and leukocyte alterations in surgically treated endometrial cancer patients: A monoinstitutional study

The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer

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