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Key points
DNA methylation may play an important role in regulating gene expression in skeletal muscle to adapt to physical activity and inactivity.
Neuronal nitric oxide synthase (nNOS) in skeletal muscle is a key regulator of skeletal muscle mass; however, it is unclear whether nNOS expression is regulated by DNA methylation.
We found that 1 week of cast immobilization increased nNOS DNA methylation...
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