Search results for: Gerd Schmitz

Items from 1 to 20 out of 245 results

article

The dysregulation of metabolic pathways and induction of the pentose phosphate pathway in renal ischaemia–reperfusion injury

Angelique ML Scantlebery, Alessandra Tammaro, James D Mills, Elena Rampanelli, more

The Journal of Pathology > 253 > 4 > 404 - 414

Lipid accumulation is associated with various forms of acute renal injury; however, the causative factors and pathways underpinning this lipid accumulation have not been thoroughly investigated. In this study, we performed lipidomic profiling of renal tissue following ischaemia–reperfusion injury (IRI). We identified a significant accumulation of cholesterol and specific phospholipids and sphingolipids...

article

Competencies for rating perceived exertion in amateur soccer players with and without intellectual disabilities

Gerd Schmitz, Jakob M. Meis, Matthias Hafferkamp, Sabine Schmitz

Journal of Applied Research in Intellectual Disabilities > 33 > 2 > 248 - 257

Background Perception of exertion is essential for self‐regulation in sports. The ability to rate perceived exertion (RPE) is regarded as psychophysiological competence, although cognitive components of RPE are largely unknown. The present study tested the hypothesis that cognitive processing speed, perseveration and figural fluency correlate with RPE. Methods The present study tested relationships...

article

Milk consumption does not prevent but induces type 2 diabetes

Bodo C. Melnik, Gerd Schmitz

Diabetes/Metabolism Research and Reviews > 35 > 8 > n/a - n/a

article

Nonglucuronidated Ezetimibe Disrupts CD13‐ and CD64‐Coassembly in Membrane Microdomains and Decreases Cellular Cholesterol Content in Human Monocytes/Macrophages

Evelyn Orsó, Horst Robenek, Alfred Boettcher, Zsuzsanna Wolf, more

Cytometry Part A > 95 > 8 > 869 - 884

Ezetimibe (EZE) and glucuronidated EZE (EZE‐Glu) differentially target Niemann‐Pick C1‐like 1 (NPC1L1) and CD13 (aminopeptidase‐N) to inhibit intestinal cholesterol absorption and cholesterol processing in other cells, although the precise molecular mechanisms are not fully elucidated. Cellular effects of EZE, EZE‐Glu, and the low‐absorbable EZE‐analogue S6130 were investigated on human monocyte‐derived...

article

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods

Dieter Lütjohann, Ingemar Björkhem, Silvia Friedrichs, Anja Kerksiek, more

The Journal of Steroid Biochemistry and Molecular Biology > 2019 > 190 > C > 115-125

Serum concentrations of lathosterol, the plant sterols campesterol and sitosterol and the cholesterol metabolite 5α-cholestanol are widely used as surrogate markers of cholesterol synthesis and absorption, respectively. Increasing numbers of laboratories utilize a broad spectrum of well-established and recently developed methods for the determination of cholesterol and non-cholesterol sterols (NCS)...

article

Compositional Changes Among Triglycerides and Phospholipids During FATP4 Sensitization with Palmitate Lead to ER Stress in Cultured Cells

Jessica Seessle, Gerhard Liebisch, Gerd Schmitz, Wolfgang Stremmel, more

European Journal of Lipid Science and Technology > 121 > 5 > n/a - n/a

FATP4 expression is upregulated in acquired obesity and polymorphisms in the FATP4 gene are associated with increased blood triglycerides (TG). Since non‐alcoholic fatty liver disease (NAFLD) is a manifestation of obesity, it is of interest to understand how FATP4 upon fat overload mediates alterations of lipids that lead to pathogenesis of fatty liver. A model system with FATP4‐overexpressed (FATP4)...

article

Training proprioception with sound: effects of real‐time auditory feedback on intermodal learning

Shashank Ghai, Gerd Schmitz, Tong‐Hun Hwang, Alfred O. Effenberg

Annals of the New York Academy of Sciences > 1438 > 1 > 50 - 61

Our study analyzed the effects of real‐time auditory feedback on intermodal learning during a bilateral knee repositioning task. Thirty healthy participants were randomly allocated to control and experimental groups. Participants performed an active knee joint repositioning task for the four target angles (20°, 40°, 60°, and 80°) bilaterally, with or without additional real‐time auditory feedback...

article

Exosomes of pasteurized milk: potential pathogens of Western diseases

Bodo C. Melnik, Gerd Schmitz

Journal of Translational Medicine > 2019 > 17 > 1 > 1-33

Milk consumption is a hallmark of western diet. According to common believes, milk consumption has beneficial effects for human health. Pasteurization of cow’s milk protects thermolabile vitamins and other organic compounds including bioactive and bioavailable exosomes and extracellular vesicles in the range of 40–120 nm, which are pivotal mediators of cell communication via systemic transfer of specific...

article

Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney

Elena Rampanelli, Peter Ochodnicky, Johannes PC Vissers, Loes M Butter, more

The Journal of Pathology > 246 > 4 > 470 - 484

Obesity and dyslipidaemia are features of the metabolic syndrome and risk factors for chronic kidney disease. The cellular mechanisms connecting metabolic syndrome with chronic kidney disease onset and progression remain largely unclear. We show that proximal tubular epithelium is a target site for lipid deposition upon overnutrition with a cholesterol‐rich Western‐type diet. Affected proximal tubule...

article

Correlations between executive functions and adaptation to incrementally increasing sensorimotor discordances

Gerd Schmitz, Mirco Dierking, Anthea Guenther

Experimental Brain Research > 2018 > 236 > 12 > 3417-3426

A previous study reported that movement directions adapt much better to 60° target displacements (double steps) when target displacements are introduced incrementally and not abruptly. The present study tested whether incremental adaptation to 60° discordances can be explained by specific cognitive abilities. The results showed that an increase of discordance size during adaptation enhanced reaction...

article

Acceleration and deceleration at constant speed: systematic modulation of motion perception by kinematic sonification

Alfred O. Effenberg, Gerd Schmitz

Annals of the New York Academy of Sciences > 1425 > 1 > 52 - 69

Many domains of human behavior are based on multisensory representations. Knowledge about the principles of multisensory integration is useful to configure real‐time movement information for the online support of perceptuomotor processes (motor perception, control, and learning). A powerful method for generating real‐time information is movement sonification. Remarkable evidence exists on movement‐acoustic...

article

Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome

Lotte Kors, Elena Rampanelli, Geurt Stokman, Loes M. Butter, more

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease > 2018 > 1864 > 5(PA) > 1883-1895

NOD-like receptor (NLR)X1 (NLRX1) is an ubiquitously expressed inflammasome-independent NLR that is uniquely localized in mitochondria with as yet unknown effects on metabolic diseases. Here, we report that NLRX1 is essential in regulating cellular metabolism in non-immune parenchymal hepatocytes by decreasing mitochondrial fatty acid-dependent oxidative phosphorylation (OXPHOS) and promoting glycolysis...

article

ApoE is a major determinant of hepatic bile acid homeostasis in mice

Sandra von Hardenberg, Carsten Gnewuch, Gerd Schmitz, Jürgen Borlak

The Journal of Nutritional Biochemistry > 2018 > 52 > C > 82-91

Apolipoprotein E (ApoE) plays a central role in lipid transport and cholesterol metabolism, with surplus cholesterol being removed from the liver through bile acid (BA) synthesis. Furthermore, BAs are of critical importance in fat absorption by forming intestinal lipid-bile salt mixed micelles. To define ApoE's role in BA homeostasis, the metabolism of cholesterol and BA was investigated in liver...

article

Zirkulierende extrazelluläre Vesikel - die Biomarker der Zukunft?!

Fouzi El Magraoui, Gerd Schmitz, Helmut E. Meyer

BIOspektrum > 2017 > 23 > 7 > 777-778

Extracellular vesicles (EV) are secreted by most cells and are present in every body fluid. They can be seen as major players in the regulation and communication of cells. They are adressed as therapeutic and diagnostic tool for many disorders including neurodegenerative diseases. Distinct subpopulations of platelet derived EVs have been shown to contain high concentrations of Alzheimer’s disease(AD)-associated...

article

Efficacy of lipid reduction with DALI and MONET

Wolfgang Ramlow, Eberhard Röseler, Franz Heigl, Ralf Spitthöver, more

Atherosclerosis Supplements > 2017 > 30 > C > 217-224

Lipidapheresis techniques are increasingly used to treat drug-resistant hyperlipidemia but few efficacy studies under routine application are available. In this multicenter observational study we investigated direct adsorption of lipoproteins (DALI) and lipoprotein filtration (MONET) for the short and the long-term effects on lipid-lowering effects.Data of 122 apheresis patients from 11 centers (DALI:...

article

Safety aspects of lipidapheresis using DALI and MONET – Multicenter observational study

Justyna Kozik-Jaromin, Eberhard Röseler, Franz Heigl, Ralf Spitthöver, more

Atherosclerosis Supplements > 2017 > 30 > C > 225-231

Lipidapheresis was introduced for intractable hyperlipidemia as a more selective therapy than plasma exchange aiming to enhance efficacy and limit side-effects. Although this therapy is regarded safe, multicenter data from routine application are limited. We investigated direct adsorption of lipoproteins (DALI) and lipofiltration (MONET) regarding the short and the long-term safety aspects.This multicenter...

article

Properties of intermodal transfer after dual visuo- and auditory-motor adaptation

Gerd Schmitz, Otmar L. Bock

Human Movement Science > 2017 > 55 > C > 108-120

Previous work documented that sensorimotor adaptation transfers between sensory modalities: When subjects adapt with one arm to a visuomotor distortion while responding to visual targets, they also appear to be adapted when they are subsequently tested with auditory targets. Vice versa, when they adapt to an auditory-motor distortion while pointing to auditory targets, they appear to be adapted when...

article

MicroRNAs: Milk's epigenetic regulators

Bodo C. Melnik, Gerd Schmitz

Best Practice & Research Clinical Endocrinology & Metabolism > 2017 > 31 > 4 > 427-442

Our perception of milk has changed from a “simple food” to a highly sophisticated maternal–neonatal nutrient and communication system orchestrating early programming of the infant. Milk miRNAs delivered by exosomes and milk fat globules derived from mammary gland epithelial cells play a key role in this process. Exosomes resist the harsh intestinal environment, are taken up by intestinal cells via...

article

Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function

Christopher Schröder, Elsa Leitão, Stefan Wallner, Gerd Schmitz, more

Epigenetics & Chromatin > 2017 > 10 > 1 > 1-18

Background There is increasing evidence for inter-individual methylation differences at CpG dinucleotides in the human genome, but the regional extent and function of these differences have not yet been studied in detail. For identifying regions of common methylation differences, we used whole genome bisulfite sequencing data of monocytes from five donors and a novel bioinformatic strategy. Results...

article

Analysis of platelet‐derived extracellular vesicles in plateletpheresis concentrates: a multicenter study

Anne Black, Evelyn Orsó, Reinhard Kelsch, Melanie Pereira, more

Transfusion > 57 > 6 > 1459 - 1469

BACKGROUND Routine quantification of platelet‐derived extracellular vesicles (PL‐EVs) may be useful in the quality control (QC) of platelet concentrates (PCs). The aim of this multicenter study was to establish and validate a consensus protocol for the standardized PL‐EV quantification using conventional flow cytometers. STUDY DESIGN AMD METHODS Eighty‐six PCs were investigated in five blood transfusion...

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MACROPHAGE (7)
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INFONA - science communication portal

Search results for: Gerd Schmitz

The dysregulation of metabolic pathways and induction of the pentose phosphate pathway in renal ischaemia–reperfusion injury

Competencies for rating perceived exertion in amateur soccer players with and without intellectual disabilities

Milk consumption does not prevent but induces type 2 diabetes

Nonglucuronidated Ezetimibe Disrupts CD13‐ and CD64‐Coassembly in Membrane Microdomains and Decreases Cellular Cholesterol Content in Human Monocytes/Macrophages

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods

Compositional Changes Among Triglycerides and Phospholipids During FATP4 Sensitization with Palmitate Lead to ER Stress in Cultured Cells

Training proprioception with sound: effects of real‐time auditory feedback on intermodal learning

Exosomes of pasteurized milk: potential pathogens of Western diseases

Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney

Correlations between executive functions and adaptation to incrementally increasing sensorimotor discordances

Acceleration and deceleration at constant speed: systematic modulation of motion perception by kinematic sonification

Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome

ApoE is a major determinant of hepatic bile acid homeostasis in mice

Zirkulierende extrazelluläre Vesikel - die Biomarker der Zukunft?!

Efficacy of lipid reduction with DALI and MONET

Safety aspects of lipidapheresis using DALI and MONET – Multicenter observational study

Properties of intermodal transfer after dual visuo- and auditory-motor adaptation

MicroRNAs: Milk's epigenetic regulators

Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function

Analysis of platelet‐derived extracellular vesicles in plateletpheresis concentrates: a multicenter study

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