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One of the major restrictions on the production of adenoviral vectors (AdV) is the so-called “cell density effect”, i.e., a drop in cell-specific AdV productivity concomitant with increased cell concentration at infection (CCI) above 1×10 6 cell/ml. Although this “cell density effect” has been considered by several authors as a consequence of nutrient depletion and/or accumulation of byproducts,...
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