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Background To mimic systemic inflammation in humans, different animal models have been developed. Since these models are still discussed controversially, we aimed to comparatively evaluate the most widely used models with respect to the systemic effects, the influence on organ functions and to the underlying pathophysiological processes. Methods Systemic inflammation was induced in C57BL/6N mice...
BackgroundMany of the concepts describing molecular mechanisms of sepsis‐induced liver failure are derived from endotoxin models. However, the biological significance of such models is questionable as the complexity of clinical sepsis and associated organ failure is only partially replicated.
AimsComparison of cytokine response, leucocyte recruitment, oxidative stress and markers of hepatic organ...
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