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The KCNE2 gene encodes a single transmembrane domain protein that modulates a variety of K + channel functions in various tissues. Here we show that cardiac KCNE2 transcript levels are ∼10-fold upregulated at the end of pregnancy. This upregulation was mimicked by 17-β estradiol but not by 5α-dihydrotestosterone treatments in ovariectomized mice. To investigate the mechanism of KCNE2 transcriptional...
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