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Research in an emergency setting such as that with an acute cardiovascular event is challenging because the window of opportunity to treat may be short and may preclude time to obtain informed consent from the patient or their representative. Some perceive that requiring informed consent in emergency situations has limited improvements in care. Vulnerable populations including minorities or residents...
Evaluation of the effectiveness of resuscitation interventions is challenging. We describe these challenges, which include design, enrolment and analysis issues.Randomized trials establish if interventions work in predefined populations. “Efficacy” trials determine whether interventions work under ideal conditions. “Effectiveness” trials determine whether interventions work under usual practice conditions...
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