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Aims
The aim of this study was to assess the effect of FGF21 on food intake, body weight, body composition, glucose homeostasis, bone mineral density (BMD), cortisol and growth hormone (GH) in obese minipigs. The pig is a unique model for studying FGF21 pharmacology as it does not express UCP1, unlike mice and humans.
Methods
Twelve obese Göttingen minipigs with a mean body weight of 91.6 ± 6.7...
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