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Data generated in the Plasmodium yoelii rodent model indicated that plasmid DNA vaccines encoding the P. yoelii circumsporozoite protein (PyCSP) or 17 kDa hepatocyte erythrocyte protein (PyHEP17) were potent inducers of protective CD8 + T cell responses directed against infected hepatocytes. Immunization with a mixture of these plasmids circumvented the genetic restriction of protective immunity...
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