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Secretory phospholipase A 2 (sPLA 2 ) exhibits neurotoxicity in the central nervous system. There are high-affinity binding sites of the porcine pancreatic group IB sPLA 2 (sPLA 2 -IB) in the brain. sPLA 2 -IB causes neuronal cell death via apoptosis in the rat cerebral cortex. Although apoptosis is triggered by an influx of Ca 2+ into neurons,...
In primary cultures of rat cortical neurons, group IB secretory phospholipase A 2 (sPLA 2 -IB) induced cell death. In rat cortical membranes, there were high affinity binding sites of [ 125 I]sPLA 2 -IB. The high-affinity binding sites were decreased by sPLA 2 -IB and anti-sPLA 2 receptor immunoglobulin G (anti-sPLA 2 R IgG). Furthermore,...
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