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Tumors interact reciprocally with their hosts’ physiology and metabolism, making cancer a systemic disease. In this issue of Cell Metabolism, Borniger et al. (2018) demonstrate this phenomenon by linking the endocrine control of food intake with sleep behavior and liver metabolism in a mouse model of non-metastatic breast carcinoma.
In patients with cancer, the wasting syndrome, cachexia, is associated with caloric deficiency. Here, we describe tumor-induced alterations of the host metabolic response to caloric deficiency that cause intratumoral immune suppression. In pre-cachectic mice with transplanted colorectal cancer or autochthonous pancreatic ductal adenocarcinoma (PDA), we find that IL-6 reduces the hepatic ketogenic...
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