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Developing delivery vehicles capable of penetrating cell barriers is critical for drug delivery to the brain due to the presence of the blood–brain barrier (BBB). Cell-penetrating peptides (CPPs) are one potential solution since they can enter cells; however, it is unclear whether CPPs can pass through cell barriers. In this study, the ability of the TAT CPP to cross an endothelial barrier without...
There is a great need for the development of vehicles capable of delivering therapeutic cargoes across the blood–brain barrier (BBB) and into brain cells. Cell-penetrating peptides (CPPs), such as TAT, present one such solution, and have been used successfully in vivo to deliver neuroprotective cargoes to the brain in models of stroke and seizure. However, a significant discrepancy exists in the literature,...
Activated astrocytes have been implicated in the deleterious cascade of events immediately following traumatic brain injury (TBI). In this study, primary astrocytes were activated by a well-characterized stretch injury model of TBI. Nitrite production, an outcome measure for activation in astrocytes, increased significantly after injury. Using the cell-penetrating peptide (CPP) TAT, delivery of a...
Therapeutic delivery into the brain parenchyma is difficult due to the presence of the blood-brain barrier (BBB). One potential solution is to use cell-penetrating peptides (CPPs). CPPs are short peptides made up of primarily positively charged amino acids that have the ability to transduce cell membranes and deliver cargoes to cells. It is unclear, however, whether CPPs can penetrate cell barriers,...
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