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Advancing age is the most powerful predictor of cardiovascular morbidity, mortality, and disability. Age has traditionally been ignored as a risk factor for cardiovascular disease because it is considered a non-modifiable risk. However, close examination of the age-associated changes in cardiovascular structure and function may help explain why aging is such a strong predictor of adverse events. Findings...
The world population in both industrialized and developing countries is aging. For example, in the United States, 35 million people are over the age of 65 years, and the number of older Americans is expected to double by the year 2030. The clinical and economic implications of this demographic shift are staggering because age is the most powerful risk factor for cardiovascular diseases (CVDs). The...
Recent experimental and theoretical studies demonstrate that the sinoatrial node cells (SANCs), the primary pacemaker cells of heart, operate as a complex system of functionally coupled sarcolemmal and intracellular proteins. The proteins of this system dynamically (beat-to-beat) interact throughout the entire pacemaker cycle via membrane voltage and local subsarcolemmal Ca2+ changes. Furthermore,...
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