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Opioid peptide receptor (OPR) and β-adrenergic receptor (β-AR) are well-established members of G-protein-coupled receptor (GPCR) superfamily and are involved in regulating cardiac contractility, energy metabolism, myocyte survival or death. OPRs are typical G i /G o -coupled receptors and activated by opioid peptides derived from the endorphin, dynorphin and enkephalin families, whereas...
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