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Na+/H+ exchanger 1 (NHE1), a primary regulator of intracellular pH (pHi) and extracellular pH (pHe), plays a significant role in acidifying the tumor microenvironment, possibly resulting in their malignant potential. However, currently, very little is known about the roles of NHE1 in invasion of hepatocellular carcinoma (HCC) cells. We have recently shown that NHE1 is over-expressed in HCC tissues...
The activation of Na+/H+ exchanger 1 (NHE1) is involved in the formation of tumor cell pseudopodia, possibly resulting in their malignant potential. The clinicopathological significance of NHE1, however, is not yet well known in the case of hepatocellular carcinoma (HCC). In this study, we first analyzed the NHE1 expression in 100 cases of hepatocellular carcinoma (HCC) and found that NHE1, at both...
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