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Hindlimb unloading can induce the cardiac atrophy and diminished cardiac function, however, the mechanisms responsible for which remain elusive. The chronic volume unloading of heart, which decreases the local mechanical stress, may lead to cardiac atrophy after hindlimb unloading. Many studies showed that integrin signaling, p38 MAPK, Heat shock protein 27 and cytoskeleton involved in the hypertrophic...
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