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Corticosteroids have been shown to exert direct inhib‑ itory action on the muscle‑type nicotinic acetylcholine re‑ ceptor (AChR) and therefore can promote pharmacological muscle denervation. The mechanism of hydrocortisone (HC) blockade of AChR has not been fully established. It is uncommon for an electrically neutral molecule, e.g. HC, to induce voltage‑dependent changes in AChR kinetics. Our experiments...
Our present construction of multisensory system is a result of six years of mostly unsuccessful attempts. At first, we had try to grow cells on round filter and then sandwich filter with cells between to flat multiprobe electrodes. This failed because handling the thin and flexible filter during assembling of the device usually damaged the cell monolayer. Secondly, we tried to exchange the medium...
Cystic fibrosis is the most common fatal human genetic disorder. It is caused by mutation of chloride channel protein called CFTR. CFTR channel plays a role in osmotic driven water transportacross epithelial cell monolayer. The defective water transport leads to dense viscous mucus secretion which blocks pancreatic juice production and the clearance of lung fluid. The viscous mucus leads to opportunistic...
Transient cerebral ischemia is known to induce endogenous adaptive mechanisms such as the activation of mitochondrial ATP regulated or Ca2+ regulated large conductance potassium channels that can prevent or delay neuronal injury. However, molecular mechanism of this effect remains unclear. In this study, a single channel activity was measured with patch-clamp of the mitoplasts isolated from gerbil...
Transient cerebral ischemia is known to induce endogenous adaptive mechanisms such as the activation of mitochondrial ATP-sensitive potassium channels or calcium-sensitive largeconductance potassium channels that can prevent or delay neuronal injury. In this study a single channel activity was measured after patch-clamp of the mitoplasts isolated from control gerbil hippocampus. In 70% of the all...
The mitochondrial ATP-regulated potassium (mitoKATP) channel has been suggested as trigger and effector in myocardial ischemic preconditioning. However, molecular and pharmacological properties of the mitoKATP channel remain unclear. In the present study, single-channel activity was measured after reconstitution of the inner mitochondrial membrane from bovine ventricular myocardium into bilayer lipid...
The mitochondrial ATP-regulated potassium (mitoKATP) channel has been suggested as trigger and effector in myocardial ischemic preconditioning. However, molecular and pharmacological properties of the mitoKATP channel remain unclear. In the present study, single-channel activity was measured after reconstitution of the inner mitochondrial membrane from bovine ventricular myocardium into bilayer lipid...
This paper proposes a new double-chamber model (DCM) of ion channels. The model ion channel consists of a series of three pores alternating with two chambers. The chambers are net negatively charged. The chamber’s electric charge originates from dissociated amino acid side chains and is pH dependent. The chamber’s net negative charge is compensated by cations present inside the chamber and in a diffuse...
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