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Quantitative PET studies of neuroreceptor tracers typically require that arterial input function be measured. The aim of this study was to explore the use of a population-based input function (PBIF) and an image-derived input function (IDIF) for [ 11 C](R)-rolipram kinetic analysis, with the goal of reducing – and possibly eliminating – the number of arterial blood samples needed to measure...
[ 11 C](R)-rolipram provides a measure of the density of phosphodiesterase 4 (PDE4) in brain, an enzyme that metabolizes cAMP. The aims of this study were to perform kinetic modeling of [ 11 C](R)-rolipram in healthy humans using an arterial input function and to replace this arterial input in humans with an image-derived input function.Twelve humans had two injections of [ 11...
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