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P-glycoprotein (P-gp) is an ATP-dependent efflux pump protecting the body against xenobiotics. The in vitro characterized modulator 6,7-dimethoxy-2-(6-methoxy-naphthalen-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline (MC80) of the P-gp pump was labelled with 11 C and evaluated in vivo for its potential to image P-gp function and expression. Radiochemical pure (>98%) [ 11 C]MC80 was...
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