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In order to design a potential drug, it is important to know its pK a because the protonation state of the molecule will be critical for ligand–receptor interaction and for the pharmacokinetic of the molecule. pK a values of a series of 1-(substitutedphenyl)-4-propylpiperazines were measured to study how the presence of a substituent on the phenyl ring modulates the basicity of N-4...
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