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Anders als andere nichtnucleosidische Inhibitoren der Reversen Transkriptase (NNRTI, Bindungsstelle blau hervorgehoben) von HIV‐1 konkurriert DAVP‐1 mit dem Nucleotidsubstrat. Eine Röntgenstrukturanalyse von nichtligierter Reverser Transkriptase mit gebundenem DAVP‐1 zeigt die neue Bindungsstelle nahe dem aktiven Polymerasezentrum. (Die Bindungsstelle für nucleosidanaloge Inhibitoren der Reversen...
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