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We recently reported that several sulfate-containing glycosaminoglycans, a class of compounds associated with the β-amyloid plaques of Alzheimer's disease, attenuate the toxic effects of β-amyloid fragments β25-35 and β1-40. The amyloid-binding sulfonated dye Congo Red was shown to have a similar effect. Using two clonal cell lines, we now demonstrate that several sulfonated dyes attenuate β-amyloid...
Glycosaminoglycan (GAG)-containing proteoglycans are associated with the neuritic plaques and cerebrovascular β-amyloid deposits of Alzheimer's disease as well as with the amyloid deposits of prion and other disorders. GAGs and other sulfate-containing compounds have previously been shown to bind β-amyloid peptide in vitro, suggesting possible effects on β-amyloid deposition and/or toxicity in vivo...
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