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The antibacterial action of large (>10 nm) spherical gold nanoparticles is demonstrated by Elena P. Ivanova and co‐workers in article number 2005679 to be attributed to the combined stretching and rupture of the bacterial cell membrane. The newly discovered mechanical modes of antibacterial action pose varied implications for the use and application of nanomaterials. The mechanical killing of bacteria...
It is commonly accepted that nanoparticles (NPs) can kill bacteria; however, the mechanism of antimicrobial action remains obscure for large NPs that cannot translocate the bacterial cell wall. It is demonstrated that the increase in membrane tension caused by the adsorption of NPs is responsible for mechanical deformation, leading to cell rupture and death. A biophysical model of the NP–membrane...
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